期刊
ADDICTIVE BEHAVIORS
卷 29, 期 4, 页码 673-684出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.addbeh.2004.02.010
关键词
double blindness; placebo effect; nicotine replacement; compliance; review
资金
- NIDA NIH HHS [P50 DA 13333] Funding Source: Medline
While clinical trials of medications often use a double-blind procedure, the integrity of the blind and its relationship to treatment outcome is seldom examined. In this review, 73 double-blind, placebo-controlled clinical trials of the nicotine replacement therapies (NRTs) in smoking cessation were identified. Seventeen articles were found that assessed blindness integrity, demonstrating major variations in the assessment, analysis, and reporting of blindness integrity. Although 12 studies found that subjects accurately judged treatment assignment at a rate significantly above chance, the available literature does not permit definitive conclusions about blindness integrity. Recommendations for the assessment, analysis, and reporting of blindness integrity are made. (C) 2004 Elsevier Ltd. All rights reserved.
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