期刊
MULTIPLE SCLEROSIS JOURNAL
卷 10, 期 -, 页码 S62-S62出版社
SAGE PUBLICATIONS LTD
DOI: 10.1191/1352458504ms1033oa
关键词
primary progressive MS; interferon beta-1b; MRI; EDSS; MSFC
This short monograph describes a trial of interferon beta-1b in patients with primary progressive multiple sclerosis (PPMS) or transitional MS. Designed as a randomized, placebo-controlled pilot, the trial randomly placed 73 eligible patients into two groups, placebo or interferon beta-1b 8 MIU given subcutaneously every other day for two years. Significant differences favouring interferon beta-1b in the MSFC score, T2 lesion volume and T1 lesion volume at 24 months were observed. Further study of interferon beta-1b therapy in PPMS patients is warranted.
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