期刊
ANNALS OF PHARMACOTHERAPY
卷 38, 期 6, 页码 986-988出版社
HARVEY WHITNEY BOOKS CO
DOI: 10.1345/aph.1D354
关键词
hip prosthesis infection; linezolid; multidrug-resistant Staphylococcus epidermidis
OBJECTIVE: To report a case of Staphylococcus epidermidis infection of a hip prosthesis successfully treated with oral linezolid. CASE SUMMARY: A 46-year-old woman developed methicillin-resistant S. epidermidis (MRSE) infection of her prosthetic hip. She received oral linezolid 600 mg twice daily for one month; after that time, the biological inflammatory markers returned to normal. DISCUSSION: One of the most serious complications of arthroplasty is joint prosthesis infection. It is mainly caused by gram-positive bacteria, in particular those of the genus staphylococcus. The increasing prevalence of gram-positive cocci that are resistant to antimicrobial agents has complicated the treatment of serious infections. CONCLUSIONS: Oral linezolid appears to be an effective and well-tolerated treatment option for hip prosthesis infections due to MRSE.
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