期刊
CLINICAL NEUROLOGY AND NEUROSURGERY
卷 106, 期 3, 页码 223-229出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.clineuro.2004.02.019
关键词
multiple sclerosis; brain tissue; differential gene expression; chronic active lesions; chronic silent lesions
Multiple sclerosis, a primary autoimmune disease of the central nervous system has been characterized by the presence of the demyelinating lesions (plaques) in the CNS. To further understand the gene transcription status of the two most common lesions, chronic active and chronic inactive, we have performed a cDNA microarray analysis of these two lesion type. Comparative analysis of differential gene expression of chronic active and inactive lesions have confirmed the existence of a significant difference in the transcriptional profiles of these two lesion types in both marginal and central areas. Different sets of genes were highlighted, including genes of inflammatory characteristics, apoptosis related and stress-induced, indicating their potential role in MS pathogenesis. (C) 2004 Elsevier B.V. All rights reserved.
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