期刊
AMINO ACIDS
卷 47, 期 6, 页码 1267-1271出版社
SPRINGER WIEN
DOI: 10.1007/s00726-015-1961-x
关键词
R3B1-22R; Europium; Relaxin family peptide receptor-3 (RXFP3); Relaxin-3
资金
- NHMRC [APP1066369, APP1065481]
- Victorian Government Operational Infrastructure Support Program
Relaxin-3 and its endogenous receptor RXFP3 are involved in fundamental neurological signalling pathways, such as learning and memory, stress, feeding and addictive behaviour. Consequently, this signalling system has emerged as an attractive drug target. Development of leads targeting RXFP3 relies on assays for screening and ligand optimization. Here, we present the synthesis and in vitro characterization of a fluorescent europium-labelled antagonist of RXFP3. This ligand represents a cheap and safe but powerful tool for future mechanistic and cell-based receptor-ligand interaction studies of the RXFP3 receptor.
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