期刊
RESEARCH IN MICROBIOLOGY
卷 155, 期 5, 页码 370-375出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resmic.2004.01.011
关键词
modularity; bacterial diversity; signal transduction
类别
A characteristic feature of all organisms is modular organisation: the tendency for groups of genes to interact in such a way as to limit the extent of pleiotropic effects among characters belonging to different functional complexes. While the implications of modularity for the evolution of variability have been much discussed the evolutionary origins remain obscure. Here we develop a model, with special reference to signal transduction cascades of bacteria, which predicts that in the face of ecological opportunity and lateral gene transfer, selection will favour modular genome architectures because such architectures minimise the pleiotropic effects associated with accommodation of potentially beneficial foreign DNA. (C) 2004 Elsevier SAS. All rights reserved.
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