期刊
CLINICA CHIMICA ACTA
卷 344, 期 1-2, 页码 109-114出版社
ELSEVIER
DOI: 10.1016/j.cccn.2004.02.008
关键词
purine nucleoside phosphorylase; plasma; HPLC method; cancer
Background: Purine nucleoside phosphorylase (PNP) is the purine salvage enzyme that converts guanosine to guanine and inosine to hypoxanthine. Methods: 279 samples from patients with differing cancers were collected during treatment at both pre- and post-dose stages for plasma PNP activity and compared with a normal population. Results: Normal plasma PNP activity was found to be 3.2 +/- 1.4 U/l (n = 55) as compared with the cancer patients (pre-dose 12.3 +/- 7.4 U/l [n = 215] and post-dose 11.2 +/- 5.9 U/l [n = 64]). Levels of plasma PNP did not differ greatly between the different cancer types but were on average four times greater than that found in the reference population. (C) 2004 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据