期刊
SEMINARS IN NEUROLOGY
卷 24, 期 2, 页码 197-204出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-2004-830907
关键词
insecticides; organophosphate poisoning; intermediate syndrome; neuropathy; extrapyramidal parkinsonism; paralysis; neurobehavioral
Organophosphates are commonly used as pesticides around the world. Exposures to organophosphates cause a significant number of poisonings and deaths each year. Organophosphates bind and inhibit cholinesterase enzymes. Acute toxicity manifests as a cholinergic crisis with excessive glandular secretions, altered mental status, and weakness. Several delayed syndromes have also been associated with organophosphate exposure, including a myasthenic-like syndrome, peripheral neuropathies, neuropsychiatric abnormalities, and extrapyramidal disorders. Clinical features and management of organophosphate poisoning is reviewed with emphasis on those affecting the central and peripheral nervous system.
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