期刊
VIRUS RESEARCH
卷 102, 期 1, 页码 97-108出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2004.01.020
关键词
RNA silencing; RNAi; viral suppressor protein; HC-Pro; CMV 2b
类别
RNA silencing is an ancient eukaryotic pathway in which double stranded RNA (dsRNA) triggers destruction of related RNAs in the cell. Early Studies in plants pointed to a role for this pathway as a defense against Viruses. Most known plant viruses have RNA genomes and replicate via dsRNA intermediates, thereby serving as potent inducers of RNA silencing early in replication and as silencing targets later in infection. Because RNA silencing is an antiviral mechanism, it is not surprising that many plant viruses encode suppressors of RNA silencing, This review focuses on the currently known plant virus encoded Suppressors of silencing and the functional assays used to identify these proteins. Because they interfere with silencing at different points in the pathway, these viral suppressors are Powerful tools to help unravel the mechanism of RNA silencing in plants. (C) 2004 Elsevier B.V. All rights reserved.
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