期刊
EXPERIMENTAL NEUROLOGY
卷 187, 期 2, 页码 246-253出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2004.01.022
关键词
angiogenesis; neurotrophic; cytokine; brain repair; brain development; astrocyte
资金
- NINDS NIH HHS [NS-38128, NS-45189, NS-39282] Funding Source: Medline
Vascular endothelial growth factor (VEGF) is a secreted dimeric polypeptide that until recently has been believed to be a specific mitogen for endothelial cells subserving angiogenesis and permeability in development and after injury. Recent studies have depicted the localization of VEGF and its receptors on neurons and astrocytes and it has been shown to induce neuritic growth and to provide neuroprotection particularly after ischemia or spinal cord injuries. VEGF also shares common receptor signaling with the guidance molecule SEMA3A and thus could have an additional role linking the coordinated patterning of developing vascular and nervous tissue. It is now apparent that VEGF's role in nervous tissue is pleiotropic in nature, and further elucidation of its mechanisms of action may serve as a key substrate in understanding aspects of neural repair and development. (C) 2004 Elsevier Inc. All rights reserved.
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