期刊
CANCER BIOLOGY & THERAPY
卷 3, 期 6, 页码 521-527出版社
LANDES BIOSCIENCE
DOI: 10.4161/cbt.3.6.842
关键词
hereditary cancer syndromes; breast cancer; ovarian cancer; BRCA1; recombination
类别
资金
- NCI NIH HHS [R01 CA095175, R01 CA095175-02, CA95175] Funding Source: Medline
Ten years ago, a concerted effort from several labs resulted in the cloning of BRCA1, the first of two major hereditary breast/ovarian cancer predisposition genes. Since that time, BRCA1 has been linked to several key nuclear functions connected with the prevention of genomic instability. In particular, BRCA1 functions in concert with Rod51, BRCA2 and other genes to control double strand break repair (DSBR) and homologous recombination. Here, we reassess the role of BRCA1 and its associated proteins in this process.
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