Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine

Objective To document cognition and behavior at school entry in these patients. Study design Eighteen children with congenital hypothyroidism (CH; 9 severe and 9 moderate, based on a surface of the knee epiphyses at diagnosis < or greater than or equal to0.05 cm(2)) treated from a median of 14 days with a median of 12.0 mug/kg per day of levothyroxine were evaluated at 5 years, 9 months, with the McCarthy Scale and the Questionnaire for Evaluation of Social Behavior, as were 40 control children. Results The global IQs at 5 years, 9 months, were similar: medians (range) were 102 (87 to 133), 102 (84 to 135), and 115 (88 to 136) (not significant) for severe CH, moderate CH, and control children, respectively. The behavioral scores of CH children were within the normal range. However, the number of times when plasma TSH was >6.0 mIU/L during treatment was correlated positively with anxiety (P = .02) and inattention (P = .05), whereas the number of times TSH was <0.8 mIU/L was correlated with lower verbal scores (P = .05). Conclusions Children with severe CH treated early with a high dose of levothyroxine have normal global development and behaviour at school entry.