期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 89, 期 6, 页码 2963-2972出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2003-031855
关键词
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资金
- NCRR NIH HHS [M01-RR00042] Funding Source: Medline
- NHLBI NIH HHS [R01 HL107256, R01 HL091333] Funding Source: Medline
- NIDDK NIH HHS [DK-35747, DK-58108] Funding Source: Medline
Previous studies indicate that leptin secretion is regulated by insulin-mediated glucose metabolism. Because fructose, unlike glucose, does not stimulate insulin secretion, we hypothesized that meals high in fructose would result in lower leptin concentrations than meals containing the same amount of glucose. Blood samples were collected every 30 - 60 min for 24 h from 12 normal-weight women on 2 randomized days during which the subjects consumed three meals containing 55, 30, and 15% of total kilocalories as carbohydrate, fat, and protein, respectively, with 30% of kilocalories as either a fructose-sweetened [ high fructose (HFr)] or glucose-sweetened [ high glucose (HGl)] beverage. Meals were isocaloric in the two treatments. Postprandial glycemic excursions were reduced by 66 +/- 12%, and insulin responses were 65 +/- 5% lower ( both P < 0.001) during HFr consumption. The area under the curve for leptin during the first 12 h ( - 33 +/- 7%; P < 0.005), the entire 24 h ( - 21 +/- 8%; P < 0.02), and the diurnal amplitude peak - nadir) ( 24 +/- 6%; P < 0.0025) were reduced on the HFr day compared with the HGl day. In addition, circulating levels of the orexigenic gastroenteric hormone, ghrelin, were suppressed by approximately 30% 1 - 2 h after ingestion of each HGl meal ( P < 0.01), but postprandial suppression of ghrelin was significantly less pronounced after HFr meals ( P< 0.05 vs. HGl). Consumption of HFr meals produced a rapid and prolonged elevation of plasma triglycerides compared with the HGl day ( P < 0.005). Because insulin and leptin, and possibly ghrelin, function as key signals to the central nervous system in the long-term regulation of energy balance, decreases of circulating insulin and leptin and increased ghrelin concentrations, as demonstrated in this study, could lead to increased caloric intake and ultimately contribute to weight gain and obesity during chronic consumption of diets high in fructose.
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