期刊
DEVELOPMENTAL DYNAMICS
卷 230, 期 2, 页码 210-215出版社
WILEY
DOI: 10.1002/dvdy.20042
关键词
sex determination; ovary; coelomic vessel; germ cells; follistatin; Wnt4
资金
- NCI NIH HHS [CA09541] Funding Source: Medline
- NICHD NIH HHS [HD32067, R01 HD039963] Funding Source: Medline
- PHS HHS [HE39963] Funding Source: Medline
Wnt4(-/-) XX gonads display features normally associated with testis differentiation, suggesting that WNT4 actively represses elements of the male pathway during ovarian development. Here, we show that follistatin (Fst) which encodes a TGFbeta superfamily binding protein, is a downstream component of Wnt signaling. Fst inhibits formation of the XY-specific coelomic vessel in XX gonads. In addition, germ cells in the ovarian cortex are almost completely lost in both Wnt4 and Fst null gonads before birth. Thus, we propose that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary. (C) 2004 Wiley-Liss, Inc.
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