期刊
ANALYTICAL BIOCHEMISTRY
卷 329, 期 1, 页码 21-27出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2003.12.033
关键词
diclofenac sodium; dissolved oxygen; parallel catalytic hydrogen wave; catalytic hydrogen wave; pharmaceutical analysis
The polarographic response characteristics of diclofenac sodium were investigated in 0.25 M HAc-NaAc (pH 5.0) supporting electrolyte in the absence and the presence of dissolved oxygen. The results demonstrate that the reduction peak at ca. -1.10 V is a catalytic hydrogen wave after deaeration, and the reduction peak in the presence of dissolved oxygen is a so-called parallel catalytic hydrogen wave. Based on the parallel catalytic hydrogen wave, a novel method has been proposed for the determination of diclofenac sodium by single-sweep polarography. The calibration Curve is linear in the range 1.2 x 10(-7)-2.6 x 10(-6) M and the detection limit is 6.0 x 10(-8) M. The proposed method is applied to the direct determination of diclofenac sodium in tablet forms and biological samples. (C) 2004 Elsevier Inc. All rights reserved.
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