期刊
AMERICAN JOURNAL OF DERMATOPATHOLOGY
卷 26, 期 3, 页码 177-181出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00000372-200406000-00001
关键词
apoptosis; keratinocyte; proliferating cell nuclear antigen; TUNEL; survivin
类别
资金
- NCRR NIH HHS [K23RR17525, K23 RR017525] Funding Source: Medline
- NIAMS NIH HHS [R03 AR048953-02, R03AR048953, K08 AR048618, K08 AR048618-04, R03 AR048953, KO8AR48618] Funding Source: Medline
The dysregulation of apoptosis occurs in many cutaneous disease states. Several apoptosis inhibitors have been shown elevated in neoplasms and in some inflammatory conditions, but their relation to proliferative and apoptotic states has not been defined. We examined the expression of the apoptosis inhibitor survivin in a panel of keratinocytic neoplasms and hyperproliferative skin lesions using both immunohistochemistry and a newly developed in situ hybridization technique. Proliferation and apoptotic indices were also assessed by immunohistochemical staining for proliferating cell nuclear antigen and TUNEL, respectively. We found the highest rate of proliferation in verrucae and psoriasis followed by actinic keratosis, squamous and basal cell carcinoma, lichen simplex chronicus, and seborrheic keratosis; all were significantly (P < 0.05) higher than normal skin. Apoptotic rate was increased in squamous (P = 0.05) and basal cell carcinoma (P = 0.03), but not significantly different from normal skin in the other lesions tested. Survivin expression was seen in most neoplasms and hyperproliferative lesions, but not normal skin. Survivin expression was often restricted to the upper third of the epidermis in psoriasis and lichen simplex chronicus, whereas all the other lesions stained diffusely. Survivin expression appears to be a consistent feature of keratinocytic neoplasms and hyperproliferative lesions and may contribute to the formation of epidermal hyperplasia seen in all of these disease states.
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