期刊
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
卷 14, 期 3, 页码 255-271出版社
HUMAN KINETICS PUBL INC
DOI: 10.1123/ijsnem.14.3.255
关键词
protein and carbohydrate supplement; stable isotopes
资金
- NCRR NIH HHS [M01 RR 00073] Funding Source: Medline
- NIA NIH HHS [AG-98-006] Funding Source: Medline
- NIDDK NIH HHS [DK 38010] Funding Source: Medline
This study tests the hypotheses that (a) a mixture of whey protein, amino acids (AA), and carbohydrates (CHO) stimulates net muscle protein synthesis to a greater extent than isoenergetic CHO alone after resistance exercise; and (b) that the stimulatory effect of a protein, AA, and CHO mixture will last beyond the 1st hour after intake. Eight subjects participated in 2 trials. In one (PAAC), they ingested 77.4 g CHO, 17.5 g whey protein, and 4.9 g AA I hr after resistance exercise. In the other (CON), 100 g CHO was ingested instead. They received a primed constant infusion of L-[H-2(5)]-phenylalanine, and samples from femoral artery and vein, and biopsies from vastus lateralis were obtained. The area under the curve for net uptake of phenylalanine into muscle above pre-drink value was 128 +/- 42 mg (.) leg(-1) (PAAC) versus 32 +/- 10 mg (.) leg(-1) (CON) for the 3 hr after the drink (p =.04). The net protein balance response to the mixture consisted of two components, one rapid immediate response, and a smaller delayed response about 90 min after drink, whereas in CON only a small delayed response was seen. We conclude that after resistance exercise, a mixture of whey protein, AA, and CHO stimulated muscle protein synthesis to a greater extent than isoenergetic CHO alone. Further, compared to previously reported findings, the addition of protein to an AA + CHO mixture seems to extend the anabolic effect.
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