期刊
PLASMA PROCESSES AND POLYMERS
卷 1, 期 1, 页码 63-72出版社
WILEY-BLACKWELL
DOI: 10.1002/ppap.200400013
关键词
cell adhesion; cell repulsion; micropatterning; nonfouling coatings; physical masks
Mixtures of diethyl glycol dimethyl ether vapors and argon were used to feed RF (13.56 MHz) glow discharges and coat polystyrene substrates with poly(ethylene oxide) (PEO)-like thin films. Different power input values have been used to obtain coatings with different cell-adhesive properties. Cell-culture experiments showed a tight correlation between the adhesion/morphology of cultured cell-lines and the chemical composition of the coatings; the ability of PEO-like coatings to discourage or promote cell adhesion could thus easily be related to the power delivered to the plasma. Combined deposition processes of different PEO-like coatings have been performed, with the method of physical masking, to produce surfaces micro-patterned with cell-adhesive tracks alternating with cell-repulsive domains. The micro-arrangement of different cell-adhesive domains enabled the patterning of cell cultures and induced the alignment of cells along predefined directions.
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