期刊
NEUROSCIENCE LETTERS
卷 363, 期 1, 页码 65-68出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.03.042
关键词
magnetic resonance imaging; bipolar disorder; superior temporal gyrus; adolescents
资金
- NIMH NIH HHS [MH 01736, MH 30915, MH 55123, MH 59929] Funding Source: Medline
Abnormalities in left superior temporal gyrus (STG) have been reported in adult bipolar patients. However, it is not known whether such abnormalities are already present early in the course of this illness. Magnetic resonance imaging (MRI) morphometric analysis of STG was performed in 16 DSM-IV children and adolescents with bipolar disorder (mean age +/- SD 15.5 +/- 3.4 years) and 21 healthy controls (mean age +/- SD 16.9 +/- 3.8 years). Subjects underwent a 3D spoiled gradient recalled acquisition MRI examination. Using analysis of covariance with age, gender and intra-cranial brain volume as covariates, we found significantly smaller left total STG volumes in bipolar patients (12.5 +/- 1.5 cm(3)) compared with healthy controls (13.6 +/- 2.5 cm(3)) (F = 4.45, d.f. = 1, 32, P = 0.04). This difference was accounted for by significantly smaller left and right STG white matter volumes in bipolar patients. Decreased white matter connections may be the core of abnormalities in STG, which is an important region for speech, language and communication, and could possibly underlie neurocognitive deficits present in bipolar patients. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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