期刊
SCIENCE
卷 304, 期 5676, 页码 1500-1502出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1096645
关键词
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资金
- NIGMS NIH HHS [GM59136] Funding Source: Medline
Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially involving necrosis and autophagy may exist, but their relation to apoptosis and mechanisms of regulation remains unclear. We de. ne a new molecular pathway in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy. Autophagic death required the genes ATG7 and beclin 1 and was induced by caspase-8 inhibition. Clinical therapies involving caspase inhibitors may arrest apoptosis but also have the unanticipated effect of promoting autophagic cell death.
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