期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 279, 期 23, 页码 24861-24865出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M403272200
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资金
- NIGMS NIH HHS [GM18649] Funding Source: Medline
The genome of Bacillus cereus contains 26 Nudix hydrolase genes, second only to its closest relative, Bacillus anthracis which has 30. All 26 genes have been cloned, 25 have been expressed, and 21 produced soluble proteins suitable for analysis. Substrates for 16 of the enzymes were identified; these included ADP-ribose, diadenosine polyphosphates, sugar nucleotides, and deoxynucleoside triphosphates. One of the enzymes was a CDP-choline pyrophosphatase, the first Nudix hydrolase active on this substrate. Furthermore, as a result of this and previous work we have identified a new subfamily of the Nudix hydrolase superfamily recognizable by a specific amino acid motif outside of the Nudix box.
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