期刊
SCIENCE
卷 304, 期 5676, 页码 1513-1515出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1097404
关键词
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资金
- NIAID NIH HHS [AI46433] Funding Source: Medline
Gram-positive bacteria face unique challenges in generating biologically active conformations for their exported proteins because they lack a dedicated compartment for folding secreted polypeptides. We have discovered that protein secretion by way of the general secretory ( Sec) pathway in the important human pathogen Streptococcus pyogenes proceeds through a single microdomain. Unlike other mechanisms for asymmetry involving the Sec pathway, proteins destined for secretion are targeted to a single locus distal to either cell pole that has specialized to contain the Sec translocons. This subcellular organization may represent a paradigm for secretion common to other Gram-positive pathogens with profound implications for pathogenesis.
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