期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1038, 期 1-2, 页码 183-187出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2004.03.014
关键词
optimisation; solvent desorption; experimental design; factorial design; methyl salicylate; di(propylene glycol) monomethyl ether; chemical warfare agents; simulant compounds
Factorial design (FD) was applied in order to develop an optimised method for the detection of chemical warfare (CW) agent simulant compounds on Porapak Q(TM). Application of FD allowed study of the adsorption/desorption mechanism of analytes. Di(propylene glycol) monomethyl ether (DPM) and methyl salicylate (MS) were selected for study as both compounds are employed in agent simulation trials but are currently analysed by different methods. An analytical method for simultaneous determination of both compounds was developed using solvent desorption. The optimised method identified non-polar interactions as the primary adsorption/desorption mechanism. Steel tubes were shown to be more suited for sampling of simulants, due to lower variability in recovery compared to glass tubes. Atmospheric detection limits for both simulants were estimated to be 0.2 mg m(-3) allowing the trace analysis of these compounds by gas chromatography with flame ionisation detection (GC-FID). (C) 2004 Elsevier B.V. All rights reserved.
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