期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 11, 页码 2843-2846出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.03.046
关键词
kojic acid; tyrosinase; inhibitor; peptide; solid phase
A small library of kojic acid-tripeptides (Ko-X1X2X3) was prepared by solid-phase parallel synthesis and assayed to evaluate their tyrosinase inhibitory activity. Most of the kojic acid-tripeptides showed better activities than kojic acid. Kojic acid-FWY was the best compound, and it exhibited 100-fold tyrosinase inhibitory activity compared with kojic acid. In addition, their storage stabilities were approximately 15 times higher and their toxicity was lower than that of kojic acid. (C) 2004 Elsevier Ltd. All rights reserved.
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