期刊
CYTOKINE
卷 26, 期 5, 页码 187-194出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2004.02.007
关键词
anti-type II collagen antibody-induced arthritis; macrophage migration inhibitory factor (MIF); macrophage inflammatory protein-2 (MIP-2); matrix metalloproteinase-13 (MMP-13); rheumatoid arthritis
Objective: Previous studies have demonstrated that neutralization of macrophage migration inhibitory factor (MIF) by anti-MIF antibody decreases joint destruction in the collagen-induced arthritis model. The present study was undertaken to investigate whether selective deletion of MIF inhibits inflammation and joint destruction of the anti-type II collagen antibody (anti-CII Ab)/ lipopolysaccharide (LPS)-induced arthritis in mice, in order to determine the role of this cytokine in inflammatory arthritis. Design: Anti-CII Ab/LPS-induced arthritis was induced in MIF-deficient and wild-type mice. The effects of anti-MIF polyclonal antibody administration on anti-CII Ab-induced arthritis were also evaluated. Results: The expression of MIF protein and mRNA was induced in anti-CII Ab/LPS-induced arthritis joint tissues. Histopathological arthritis scores for synovial inflammation induced by anti-CII Ab/LPS-induced arthritis were significantly decreased in anti-MIF Ab-treated mice and in MIF-deficient mice compared to wild-type mice. In addition, mRNA levels of MMP-13 and MIP-2 in anti-CII Ab/LPS-induced arthritis joint tissues were significantly reduced in MIF-deficient mice compared to wild-type control mice. Conclusions: These results indicate that MIF plays a critical role in inflammation and joint destruction in the anti-CII Ab/LPSinduced arthritis model in mice, in part via induction of MMP-13 and neutrophil infiltration through the induction of MIP-2. (C) 2004 Elsevier Ltd. All rights reserved.
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