期刊
CIRCULATION RESEARCH
卷 94, 期 11, 页码 1408-1417出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.0000129178.56294.17
关键词
caveolae; caveolins; signaling; phenotypes; nitric oxide
资金
- NHLBI NIH HHS [R01 HL57665, HL64793, HL61371] Funding Source: Medline
Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many cellular processes, including transcytosis of macromolecules, cholesterol transport, and signal transduction. Recent insights into the physiological and pathophysiological roles of these organelles and the caveolins from genetically modified mice suggest that they may be profoundly important for postnatal cardiovascular function, including endothelial barrier function, regulation of nitric oxide synthesis, cholesterol metabolism, and cardiac function.
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