期刊
TETRAHEDRON LETTERS
卷 45, 期 25, 页码 4869-4872出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.04.149
关键词
DNA; quadruplex; G-quartets; solid-phase synthesis
A cluster of four d(TG(4)T) hexanucleotides with the 3'-ends linked together by a bunchy spacer has been synthesized and shown to form a monomolecular parallel quadruplex 5 in solution characterized by four G-quartets. H-1 NMR spectroscopy and CD thermal denaturation experiments indicate the monomolecular quadruplex (5) to be more stable than the tetramolecular counterpart [d(TG(4)T)](4). (C) 2004 Elsevier Ltd. All rights reserved.
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