期刊
CLINICAL INFECTIOUS DISEASES
卷 38, 期 12, 页码 1764-1770出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/421394
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资金
- NIAID NIH HHS [5 U01 AI 26512-14, T 32 AI 107496-06] Funding Source: Medline
The effects of therapy with glutamine and alanyl-glutamine on diarrhea and antiretroviral drug levels in patients with acquired immune deficiency syndrome ( AIDS) were examined in a randomized, double-blinded, placebo-controlled study in northeast Brazil. Patients with AIDS and with diarrhea and/or wasting were randomized into 4 groups to determine the efficacy of glutamine or high- or low-dose alanyl-glutamine given for 7 days, compared with isonitrogenous glycine given to control subjects. All patients in whom baseline antiretroviral drug levels were determined had low levels 2 h after dosing. Gastrointestinal symptom scores improved with receipt of high- dose alanyl-glutamine (P < .05) or glutamine (P < .01). Antiretroviral drug levels increased in patients given alanyl-glutamine (P < .05) or glutamine (P < .01) by 113% (P = .02) 14% (P = .01), respectively. Antiretroviral drug resistance mutations were common in all groups. The dose-related efficacy of alanyl-glutamine and glutamine in treating diarrhea and in increasing antiretroviral drug levels shows that these supplements may help to improve therapy for patients with AIDS who have diarrhea and/or wasting in developing, tropical areas.
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