期刊
JOURNAL OF INFECTIOUS DISEASES
卷 189, 期 12, 页码 2318-2322出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/421275
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资金
- FIC NIH HHS [D43 TW05572, D43 TW005572] Funding Source: Medline
- NIAID NIH HHS [T32 AI007061, U01 AI58935, U01 AI058935, AI40725] Funding Source: Medline
- NICHD NIH HHS [K12-HD00850] Funding Source: Medline
The serum vibriocidal antibody is the only recognized predictor of protection from cholera, but no seroepidemiological data have been gathered since the emergence of Vibrio cholerae O139. We assessed the association between the vibriocidal antibody titer and protection from cholera in an endemic setting. Although a higher baseline vibriocidal titer correlated with protection from V. cholerae O1, infection still developed in some contacts with very high titers. No association between baseline vibriocidal titer and protection from V. cholerae O139 infection was found. Our findings suggest that the vibriocidal antibody is an incomplete predictor of protection from V. cholerae infection.
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