期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 126, 期 23, 页码 7293-7299出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja049901o
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Self-assembled monolayers (SAMS) on glass were used as a platform to sequentially deposit fluorophores and small molecules for ion sensing. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on small molecules. The resulting libraries are easily measured and show varied responses to a series of both cations and anions. This technology is transferable from the macro- to the microscale both via microcontact printing (uCP), where the fluorophore is printed onto a glass surface, and via direct attachment of the fluorophore to microchannel walls. The ease of miniaturization of this technology may make the generation of a wide variety of simple yet efficient microarrays possible.
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