期刊
BRAIN RESEARCH
卷 1011, 期 2, 页码 243-246出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2004.03.040
关键词
depression; antidepressant; eugenol; metallothionein-III; brain-derived neurotrophic factor; BDNF
Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine. (C) 2004 Elsevier B.V. All rights reserved.
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