Enhancement of DNA vaccine potency in rhesus macaques by electroporation

The potency of an HIV DNA vaccine was enhanced in rhesus macaques by in vivo electroporation, as judged by increased onset, magnitude and duration of antibody and cell-mediated immune responses against both components of a combination Gag and Env vaccine. These data demonstrate the utility of the electroporation technology for use in large animals. (C) 2004 Elsevier Ltd. All rights reserved.