期刊
VACCINE
卷 22, 期 19, 页码 2444-2451出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2003.11.070
关键词
cholera; cholera vaccines; micronesia
Control measures to limit the spread of a cholera outbreak in Pohnpei Island (Micronesia), included mass vaccination with the single-dose live-attenuated oral cholera vaccine CVD 103-HgR as a potential adjunct measure. The outbreak provided a unique opportunity to evaluate the practicality of use and effectiveness of this vaccine. Under field conditions encountered in Pohnpei, crude vaccine efficacy was estimated at 79.2% (95% Cl: 71.9-84.6%) in the target population. Retrospective analysis suggests that mass vaccination with oral cholera vaccines can be a useful adjunct tool for controlling outbreaks, particularly if implemented early in association with other standard control measures. (C) 2004 World Health Organization. Published by Elsevier Ltd. All rights reserved.
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