期刊
MICROBES AND INFECTION
卷 6, 期 8, 页码 738-744出版社
ELSEVIER
DOI: 10.1016/j.micinf.2004.03.009
关键词
antiviral activity; HSV-2; ptcrocarnin A; modes of action
The purpose of this study was to investigate the in vitro antiviral properties of pterocarnin A. extracted from the bark of Pterocarya stenoptera (Juylandaceae). Results showed that pterocarnin A exhibited anti-herpes simplex virus (HSV) activity. It had a low selectivity index (SI) value and only possessed some level of cell cytotoxic effect at high antiviral concentrations. Mechanism studies demonstrated that pterocarnin A inhibited herpes simplex virus type 2 (HSV-2) from attaching and penetrating into cells. It also actively Suppressed HSV-2 multiplication in Vero cells even when added 12 h after infection. This observation indicated that pterocarnin A affected the late stage(s) of HSV-2 infection cycle. Pterocarnin A also significantly reduced viral infectivity at high concentrations. From these observations, it was concluded that pterocarnin A suppressed both early and late in the replication cycle of HSV-2. The various modes of action of pterocarnin A in interfering, with certain steps of viral infection thus merit further investigation. (C) 2004 Elsevier SAS. All rights reserved.
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