期刊
MOLECULAR IMMUNOLOGY
卷 41, 期 6-7, 页码 599-613出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2004.04.008
关键词
B cell antigen receptor; signal transduction; tyrosine kinase; membrane immunoglobulin; Ig alpha/beta; MAPKinase; transcription factors; co-receptors
All cells continually survey their environment and make decisions based on cues encountered. This requires specific receptors that detect such cues, then transduce signals that initiate the appropriate responses. B lymphocytes provide an archetypal model for such 'adaptive' cellular responses, where signals transmitted by the B cell Ag-receptor (BCR) influence not only cellular selection, maturation, and survival, but are imperative in generating the ultimate effector function of B cells, i.e. antibody production. While other extracellular stimuli and their cognate receptor signals can also influence B cell development, BCR-mediated signals and the way in which they are integrated and regulated are paramount in defining the cell's physiological fate. (C) 2004 Elsevier Ltd. All rights reserved.
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