期刊
INFECTION AND IMMUNITY
卷 72, 期 7, 页码 3863-3868出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.7.3863-3868.2004
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资金
- NHLBI NIH HHS [R01 HL064883, R01 HL 64883] Funding Source: Medline
- NIAID NIH HHS [R01 AI 47997, R01 AI047997] Funding Source: Medline
Chlamydiae have to replicate within a cytoplasmic vacuole in eukaryotic cells. Expansion of the chlamydia-laden vacuole is essential for chlamydial intravacuolar replication, which inevitably causes host cell cytoskeleton rearrangements. A cleavage fragment of keratin 8 corresponding to the central rod region was detected in the soluble fraction of chlamydia-infected cells. Since keratin 8 is a major component of the intermediate filaments in simple epithelial cells, cleavage of keratin 8 may increase the solubility of the host cell cytoskeleton and thus permit vacuole expansion in chlamydia-infected cells. A chlamydia-secreted protease designated CPAF (chlamydial protease/proteasome-like activity factor) was both necessary and sufficient for keratin 8 cleavage in chlamydia-infected cells, suggesting that chlamydiae have evolved specific mechanisms for modifying the host cell cytoskeleton.
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