期刊
SOUTHERN MEDICAL JOURNAL
卷 97, 期 7, 页码 699-701出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00007611-200407000-00018
关键词
bronchiolitis; chemotherapy; lung; topotecan
Topotecan HCl is an antitumor drug exhibiting topoisomerase 1-inhibitory activity. Topotecan is used in the treatment of metastatic carcinoma of the ovary and as second-line treatment of small-cell lung cancer. Reported dose-limiting adverse reactions to topotecan are primarily hematologic in nature. To date, only one other case of lung toxicity in a patient taking topotecan has been reported. The authors describe the development of obliterative bronchiolitis, as evidenced by radiographic and pulmonary function testing abnormalities, in a 61-year-old woman who presented with dyspnea, and who was receiving topotecan for peritoneal carcinomatosis.
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