Heteronuclear selective refocusing 2D NMR experiments for the spectral analysis of enantiomers in chiral oriented solvents

We report the use of carbon-proton heteronuclear selective refocusing 2D NMR experiments dedicated to the spectral analysis of enantiomers dissolved in weakly ordering chiral liquid crystalline solvents. The method permits the extraction of carbon-proton residual dipolar couplings for each enantiomer from a complex or unresolved proton-coupled C-13 spectral patterns. Illustrative examples are analysed and discussed. It is shown that an accurate determination of enantiomeric excess is possible. Copyright (C) 2004 John Wiley Sons, Ltd.