期刊
BIOCHEMICAL JOURNAL
卷 381, 期 -, 页码 19-23出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20040566
关键词
ATP synthase; cytochrome c; Mgm1p; mitochondria; rhomboid-like protease; Tim11p
资金
- NIGMS NIH HHS [R01 GM057067, GM57067] Funding Source: Medline
In Saccharomyces cerevisiae, two mitochondrial inner-membrane proteins play critical roles in organellar morphology. One is a dynamin-related GTPase, Mgm1p, which participates in mitochondrial fusion. Another is Tim11p, which is required for oligomeric assembly of F1Fo-ATP synthase, which generates ATP through oxidative phosphorylation. Our data bring these findings together and define a novel role for Mgm1p in the formation and maintenance of mitochondrial cristae. We show that Mgm1p serves as an upstream regulator of Tim11p protein stability, ATP synthase assembly, cristae morphology and cytochrome c storage within cristae.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据