期刊
JOURNAL OF IMMUNOTHERAPY
卷 27, 期 4, 页码 282-288出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002371-200407000-00004
关键词
exosome; vaccine; tumor immunity; plasmacytoma
资金
- NCI NIH HHS [CA16056] Funding Source: Medline
- NICHD NIH HHS [HD 17013, R01 HD017013] Funding Source: Medline
Exosomes are membrane-bound vesicles derived from multivesicular bodies that are externalized by cells through fusion with the plasma membrane. Exosomes have been implicated in cell-to-cell signaling, and those derived from immunologic cells may be involved in both direct and cross-presentation of antigens to T cells. The research presented here evaluated their efficacy as a prophylactic cancer vaccine in a mouse plasmacytoma model. Plasmacytoma cells were shown to release exosomes in vitro, and vaccination with a single dose (5 mug) of exosome protein protected 80% of mice against challenge with wild-type tumors. Protection could be linked to the immune system since vaccinated mice generated specific cytotoxic T lymphocytes, the effects were not seen in SCID mice, and immunity was tumor-specific. Several proteins involved in immunity, including two potential tumor antigens (PIA and intracisternal A particle protein) as well as Hsp70, were demonstrated to be present in exosomes. The authors conclude that exosomes can induce tumor-specific immunity and prevent tumor development and are a potential strategy for future therapeutic tumor vaccination.
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