期刊
EMBO REPORTS
卷 5, 期 7, 页码 686-691出版社
WILEY
DOI: 10.1038/sj.embor.7400185
关键词
chromatin domain; DNA replication; mammalian chromosomes; origins; replicators; replicon
资金
- NCI NIH HHS [T32 CA009385, CA09385] Funding Source: Medline
- NIGMS NIH HHS [GM52948, R01 GM052948] Funding Source: Medline
The origins of DNA replication were proposed in the replicon model to be specified genetically by replicator elements that coordinate the initiation of DNA synthesis with gene expression and cell growth. Recent studies have identified DNA sequences in mammalian cells that fulfil the genetic criteria for replicators and are beginning to uncover the sequence requirements for the initiation of DNA replication. Mammalian replicators are composed of non-redundant modules that cooperate to direct initiation to specific chromosomal sites. Conversely, replicators do not show strong sequence similarity, and their ability to initiate replication depends on the chromosomal context and epigenetic factors, as well as their primary sequence. Here, we review the properties of metazoan replicators, and discuss the genetic and epigenetic factors that determine where and when DNA replication is initiated.
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