期刊
BLOOD
卷 104, 期 1, 页码 227-236出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2003-09-3284
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- NCI NIH HHS [4-R44-CA85130-02, K12-CA76937, 1-R44-CA85130-01] Funding Source: Medline
Pretargeted radioimmunotherapy (PRIT) has the potential to increase the dose of radionuclide delivered to tumors while limiting radiation to normal tissues. The purpose of this phase 1 trial is to assess safety of this multistep approach using a novel tetrameric single-chain anti-CD20-streptavidin fusion protein (B9E9FP) as the targeting moiety in patients with B-cell non-Hodgkin lymphoma (NHL), and to characterize its pharmacokinetics and immunogenicity. All patients received B9E9FP (160 mg/m(2) or 320 mg/m(2)); either 48 or 72 hours later, a synthetic clearing agent (sCA) was administered (45 mg/m(2)) to remove circulating unbound B9E9FP. (90)Yttrium (Y-90; 15 mCl/m(2))/In-111 (5 mCl)-DOTA-biotin was injected 24 hours later. There were 15 patients enrolled in the study. B9E9FP had a mean plasma half-life (T-1/(2)) of 25 +/- 6 hours with a reduction in plasma level of more than 95% within 6 hours of sCA administration. Y-90/In-111-DOTA-biotin infusion resulted in rapid tumor localization and urinary excretion. The ratio of average tumor to whole-body radiation dose was 49:1. No significant hematologic toxicities were noted in 12 patients. There were 2 patients who had hematologic toxicity related to progressive disease. There were 2 complete remissions (90 and 325 days) and one partial response (297 days). B9E9FP performs well as the targeting component of PRIT with encouraging dosimetry, safety, and efficacy. A dose escalation trial of Y-90-DOTA-biotin in this format is warranted.
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