期刊
APPLIED SURFACE SCIENCE
卷 296, 期 -, 页码 95-99出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2014.01.050
关键词
Controlled release; Lipid merging; pNIPAM particle; Transformation
类别
资金
- National Science Foundation of China [21106114, 11104192, 21374074]
- Natural Science Foundation of Jiangsu Province of China [BK2012177, BK20131194]
Cell membrane changes its morphology during many physiological processes with the assistance of a solid support, such as the cytoskeleton, under an environmental stimulus. Here, a novel type of stimuli-responsive lipogel was fabricated, mimicking the changes of cell membrane. The lipogel was prepared from poly(N-isopropylacrylamide) (pNIPAM) microgel particle and phospholipid by a solvent-exchange method. The temperature dependent volume phase transition of pNIPAM triggers reversible transformation of the lipogel between a lipid vesicle-coated sun-like structure and a contracted hybrid sphere, through lipid merging and protrusion processes, respectively. By contrast, the salt induced pNIPAM phase transition leads to an irreversible vesicle release behaviour. The lipogel creates a unique platform for studying cell membrane behaviour and provides promising candidates in drug delivery and controlled release applications. (C) 2014 Elsevier B. V. All rights reserved.
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