期刊
GENE THERAPY
卷 11, 期 13, 页码 1099-1104出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.gt.3302274
关键词
heat shock; gene therapy; apoptosis; phagocytosis; transcription factor
类别
资金
- NCI NIH HHS [R01 CA094180] Funding Source: Medline
Heat shock protein expression and release is closely associated with immunogenic forms of cell death. We show that activation of the stress response within tumor cells during cell death, using an engineered form of the heat shock transcription factor, leads to an immunogenic death. Cells dying through 'stressful death' show decreased phagocytosis by macrophages in vitro. Moreover, cells expressing heat shock proteins during cell death are significantly more protective against subsequent tumor challenge. These data demonstrate the utility of activating cellular stress programs over the course of cytotoxic therapies to enhance immune responses to dying cells.
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