Pollution correlated modifications of liver antioxidant systems and histopathology of fish (Cyprinidae) living in Seyhan Dam Lake, Turkey

Specimen of freshwater fish (Cyprinidae) was collected from polluted and clean areas in dam Lake of Seyhan. Ten (n = 10) fish were taken from each site. Liver preparations of fish from the two sources were comparatively assayed for glutathione-S-transferase (GST), lactic dehydrogenase (LDH), catalase (CAT), glucose-6-phosphate dehydrogenase (G6PDH), superoxide dismutase (SOD) and malondialdehyde (MDA). All systems were significantly (p < 0.1) affected at the polluted site. The microscopic examination of the liver tissues of the fish living in the polluted area showed mononuclear inflammatory cell infiltration, cloudy degenerations, congestions and also micro- and macrovesicular fatty degenerations. These results provide evidence that both biochemical parameters and histopathological observations can be assumed as sensitive indicators of fish liver metabolism for polluted areas. (C) 2004 Elsevier Ltd. All rights reserved.