期刊
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 15, 期 7, 页码 1690-1699出版社
AMER SOC NEPHROLOGY
DOI: 10.1097/01.ASN.0000129115.69395.65
关键词
-
资金
- NIDDK NIH HHS [DK-54368, DK-59530, DK-20543] Funding Source: Medline
The transient receptor potential (TRP) superfamily of proteins is cation-selective ion channels with six predicted transmembrane segments and intracellularly localized amino and carboxyl termini. Members of the TRP superfamily are identified on the basis of amino acid sequence and structural similarity and are classified into TRPC, TRPV, TRPM, TRPP, TRPN, and TRPML subfamilies. TRP channels are widespread and have diverse functions, ranging from thermal, tactile, taste, osmolar, and fluid flow sensing to transepithelial Ca2+ and Mg2+ transport. Mutations of TRP proteins produce many renal diseases, including Mg2+ wasting, hypocalcemia, and polycystic kidney diseases. This review focuses on recent advances in the understanding of their functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据