期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 24, 期 7, 页码 744-755出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.WCB.0000122745.72175.D5
关键词
cerebral blood flow; optical imaging; metabolic coupling; hypercapnia; autoregulation; focal cerebral ischemia
资金
- NIBIB NIH HHS [R01 EB00790-01 A2] Funding Source: Medline
- NINDS NIH HHS [P01 NS35611, P50 NS10828, K25 NS041291] Funding Source: Medline
Laser speckle flowmetry (LSF) is useful to assess noninvasively two-dimensional cerebral blood flow (CBF) with high temporal and spatial resolution. The authors show that LSF can image the spatiotemporal dynamics of CBF changes in mice through an intact skull. When measured by LSF, peak CBF increases during whisker stimulation closely correlated with simultaneous laser-Doppler flowmetry (LDF) measurements, and were greater within the branches of the middle cerebral artery supplying barrel cortex than within barrel cortex capillary bed itself. When LSF was used to study the response to inhaled CO2 (5%), the flow increase was similar to the response reported using LDF. For the upper and lower limits of autoregulation, mean arterial pressure values were 110 and 40 mm Hg, respectively. They also show a linear relationship between absolute resting CBF, as determined by [C-14]iodoamphetamine technique, and 1/tau(c) values obtained using LSF, and used 1/tau(c) values to compare resting CBF between different animals. Finally, the authors studied CBF changes after distal middle cerebral artery ligation, and developed a model to investigate the spatial distribution and hemodynamics of moderate to severely ischemic cortex. In Summary, LSF has distinct advantages over LDF for CBF monitoring because of high spatial resolution.
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