期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 93, 期 1, 页码 141-146出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2004.03.048
关键词
Phellinus linteus; anti-inflammatory; antinociceptive; anti-angiogenic; chorioallantoic membrane; ear edema; folk medicine
This study aimed to elucidate the anti-inflammatory and related activities of mushroom Phellinus linteus. The results show that the EtOH extract of Phellinus linteus (PLE) dose-dependently inhibited the mouse ear edema induced by croton oil. Among PLE subfractions, the n-BuOH subtraction showed highest anti-inflammatory activity in croton oil-induced ear edema test. The n-BuOH subtraction also showed highest inhibitory activity on the chick embryo chorioallantoic membrane (CAM) angiogenesis in a dose-dependent manner. PLE could significantly reduce the number of writhing induced by acetic acid in mice, indicating that PLE possesses potent antinociceptive effect mediated by its anti-inflammatory activity. Mycelial extract of six different Phellinus strains were found to contain anti-angiogenic activity in the CAM assay. These results suggest that Phellinus linteus has anti-inflammatory and antinociceptive activities, in addition to its anti-angiogenic activity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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