期刊
APPLIED SURFACE SCIENCE
卷 288, 期 -, 页码 122-129出版社
ELSEVIER
DOI: 10.1016/j.apsusc.2013.09.159
关键词
Functionalized carbon nanotubes; Azithromycin; Cleavable bonds; Drug release; In vitro therapy
类别
资金
- Iran National Science Foundation (INSF)
Functionalization of single-walled carbon nanotubes (SWCNTs) with nitrile groups, followed by further reactions allowed direct attachment of azithromycin and its N-demethyl derivative to the side-walls of SWCNTs for the first time. With these approaches, the cleavable ester or thioamide bonds are formed to connect azithromycin to SWCNTs resulting in azithromycin-SWCNT conjugates. These cleavable bonds are able to control molecular release from nanotube surfaces which are generally applicable to a variety of hybrid materials based on SWCNTs. A non-covalent azithromycin-SWCNT has also been compared with azithromycin-SWCNTs conjugates. Thermogravimetric analysis (TGA), Fourier-transformed infrared (FTIR), UV-vis, and Raman spectroscopies give hints on the characterization of azithromycin-SWCNT. Both drug release and antimicrobial activity of azithromycin-SWCNT conjugates were also tested. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据