期刊
AGEING RESEARCH REVIEWS
卷 3, 期 3, 页码 251-263出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.arr.2004.03.001
关键词
ferritin; IRE; IRP; transferrin; absorption; DMT1
While there have been significant advances made in our understanding of the cellular and molecular mechanisms that regulate iron absorption, transport, storage, and utilization, the effect of ageing on these mechanisms and the role of iron in the ageing process is not fully understood. Thus, this review will provide an overview of the iron regulatory mechanisms that may be a factor in the ageing process. Additional reviews in this volume represent an attempt to explore the very latest information on the regulation of iron with a particular emphasis on age-related pathology including mitochondrial function, Parkinson's disease, Alzheimer's disease, stroke, and cardiovascular disease. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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